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High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD – results from the ECLIPSE study

BACKGROUND: There is a need to identify individuals with COPD at risk for disease progression and mortality. Lung tissue remodeling is associated with the release of extracellular matrix (ECM) fragments into the peripheral circulation. We hypothesized that ECM remodeling was associated with mortalit...

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Detalles Bibliográficos
Autores principales: Sand, Jannie M. B., Leeming, Diana J., Byrjalsen, Inger, Bihlet, Asger R., Lange, Peter, Tal-Singer, Ruth, Miller, Bruce E., Karsdal, Morten A., Vestbo, Jørgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050854/
https://www.ncbi.nlm.nih.gov/pubmed/27716343
http://dx.doi.org/10.1186/s12931-016-0440-6