Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver

BACKGROUND: Glycine N-methyltransferase (GNMT) is abundantly expressed in the normal liver but is down-regulated in liver cancer tissues. GNMT knockout (Gnmt−/−) mice can spontaneously develop chronic hepatitis, fatty liver, and liver cancer. We previously demonstrated that hepatic GNMT is decreased...

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Detalles Bibliográficos
Autores principales: Liao, Yi-Jen, Lee, Tzong-Shyuan, Twu, Yuh-Ching, Hsu, Shih-Ming, Yang, Ching-Ping, Wang, Chung-Kwe, Liang, Yu-Chih, Chen, Yi-Ming Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050923/
https://www.ncbi.nlm.nih.gov/pubmed/27716281
http://dx.doi.org/10.1186/s12929-016-0278-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050923/
https://www.ncbi.nlm.nih.gov/pubmed/27716281
http://dx.doi.org/10.1186/s12929-016-0278-8

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