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Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver

BACKGROUND: Glycine N-methyltransferase (GNMT) is abundantly expressed in the normal liver but is down-regulated in liver cancer tissues. GNMT knockout (Gnmt−/−) mice can spontaneously develop chronic hepatitis, fatty liver, and liver cancer. We previously demonstrated that hepatic GNMT is decreased...

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Detalles Bibliográficos
Autores principales:	Liao, Yi-Jen, Lee, Tzong-Shyuan, Twu, Yuh-Ching, Hsu, Shih-Ming, Yang, Ching-Ping, Wang, Chung-Kwe, Liang, Yu-Chih, Chen, Yi-Ming Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050923/ https://www.ncbi.nlm.nih.gov/pubmed/27716281 http://dx.doi.org/10.1186/s12929-016-0278-8

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