The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

BACKGROUND: Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating inflammation and microglial polariza...

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Detalles Bibliográficos
Autores principales: Zhao, Qiuying, Wu, Xiaohui, Yan, Shuo, Xie, Xiaofang, Fan, Yonghua, Zhang, Jinqiang, Peng, Cheng, You, Zili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051050/
https://www.ncbi.nlm.nih.gov/pubmed/27716270
http://dx.doi.org/10.1186/s12974-016-0728-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051050/
https://www.ncbi.nlm.nih.gov/pubmed/27716270
http://dx.doi.org/10.1186/s12974-016-0728-y

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