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Neuronal NTPDase3 Mediates Extracellular ATP Degradation in Trigeminal Nociceptive Pathway

ATP induces pain via activation of purinergic receptors in nociceptive sensory nerves. ATP signaling is terminated by ATP hydrolysis mediated by cell surface-localized ecto-nucleotidases. Using enzymatic histochemical staining, we show that ecto-ATPase activity is present in mouse trigeminal nerves....

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Detalles Bibliográficos
Autores principales: Ma, Lihua, Trinh, Thu, Ren, Yanfang, Dirksen, Robert T., Liu, Xiuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051867/
https://www.ncbi.nlm.nih.gov/pubmed/27706204
http://dx.doi.org/10.1371/journal.pone.0164028