The Important Role of Halogen Bond in Substrate Selectivity of Enzymatic Catalysis

The use of halogen bond is widespread in drug discovery, design, and clinical trials, but is overlooked in drug biosynthesis. Here, the role of halogen bond in the nitrilase-catalyzed synthesis of ortho-, meta-, and para-chlorophenylacetic acid was investigated. Different distributions of halogen bo...

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Detalles Bibliográficos
Autores principales: Jiang, Shuiqin, Zhang, Lujia, Cui, Dongbin, Yao, Zhiqiang, Gao, Bei, Lin, Jinping, Wei, Dongzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052520/
https://www.ncbi.nlm.nih.gov/pubmed/27708371
http://dx.doi.org/10.1038/srep34750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052520/
https://www.ncbi.nlm.nih.gov/pubmed/27708371
http://dx.doi.org/10.1038/srep34750

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