Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode

The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in the regulation of the metabolic homeostasis and therefore represent valuable therapeutic targets for the treatment of metabolic diseases. The development of more balanced drugs interacting with PPARs, devoid of...

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Detalles Bibliográficos
Autores principales: Capelli, Davide, Cerchia, Carmen, Montanari, Roberta, Loiodice, Fulvio, Tortorella, Paolo, Laghezza, Antonio, Cervoni, Laura, Pochetti, Giorgio, Lavecchia, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052532/
https://www.ncbi.nlm.nih.gov/pubmed/27708429
http://dx.doi.org/10.1038/srep34792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052532/
https://www.ncbi.nlm.nih.gov/pubmed/27708429
http://dx.doi.org/10.1038/srep34792

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