Cargando…

Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer’s disease treatment

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by genotypic and phenotypic heterogeneity. Critical components of the two AD pathological pathways, Aβ-amyloidosis and Tauopathy, have been considered as therapeutic targets. Among them, much effort is focused on aberrant Tau phos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Wenchao, Lee, Seongsoo, Huang, Xiaoran, Liu, Song, Inayathullah, Mohammed, Kim, Kwang-Min, Tang, Hongxiang, Ashford, J. Wesson, Rajadas, Jayakumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052533/ https://www.ncbi.nlm.nih.gov/pubmed/27708431 http://dx.doi.org/10.1038/srep34784

Ejemplares similares

Effect of osmolytes on the conformation and aggregation of some amyloid peptides: CD spectroscopic data
por: Inayathullah, Mohammed, et al.
Publicado: (2016)

Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition
por: Wagh, Dhananjay, et al.
Publicado: (2015)

Skin Flap Necrosis by Bone Marking with Methylene Blue in Cochlear Implantation
por: Kim, Yeon Hoo, et al.
Publicado: (2015)

The Dichotomy of Alzheimer’s Disease Pathology: Amyloid-β and Tau
por: Ashford, J. Wesson
Publicado: (2019)

Repurposing Disulfiram (Tetraethylthiuram Disulfide) as a Potential Drug Candidate against Borrelia burgdorferi In Vitro and In Vivo
por: Potula, Hari-Hara S. K., et al.
Publicado: (2020)

In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau
por: Zhang, Shengnan, et al.
Publicado: (2018)

Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity
por: Ando, Kanae, et al.
Publicado: (2016)

Methylene Blue Blocks and Reverses the Inhibitory Effect of Tau on PMCA Function
por: Berrocal, Maria, et al.
Publicado: (2019)

Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice
por: Hosokawa, Masato, et al.
Publicado: (2012)

Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology
por: Huang, Yongqi, et al.
Publicado: (2023)

CORRELATION OF OXIDATION AND PHOSPHORYLATION IN HEMOLYZED BLOOD IN PRESENCE OF METHYLENE BLUE AND PYOCYANINE
por: Runnström, John, et al.
Publicado: (1935)

PEG/Dextran Double Layer Influences Fe Ion Release and Colloidal Stability of Iron Oxide Nanoparticles
por: Mohammadi, M. Rezaa, et al.
Publicado: (2018)

A Novel Interaction between MFN2/Marf and MARK4/PAR-1 Is Implicated in Synaptic Defects and Mitochondrial Dysfunction
por: Cheon, Yeongmi, et al.
Publicado: (2023)

Oblique radiograph with methylene blue marking: A reliable technique for upper thoracic level localization
por: Huang, He, et al.
Publicado: (2023)

Methylene Blue: Revisited
por: Ginimuge, Prashant R., et al.
Publicado: (2010)

Methylene-Blue in Fevers
por: Frost, G. H.
Publicado: (1908)

Adsorption of Methylene Blue on Bituminous Coal: Adsorption Mechanism and Molecular Simulation
por: Huang, Bo, et al.
Publicado: (2019)

Solvent Microenvironments and Copper Binding Alters the Conformation and Toxicity of a Prion Fragment
por: Inayathullah, Mohammed, et al.
Publicado: (2013)

Paint It Blue: Methylene Blue in Burn Care
por: Goodenough, Christopher J., et al.
Publicado: (2020)

MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer’s disease granulovacuolar degeneration bodies
por: Lund, Harald, et al.
Publicado: (2014)

Rationally Designed Turn Promoting Mutation in the Amyloid-β Peptide Sequence Stabilizes Oligomers in Solution
por: Rajadas, Jayakumar, et al.
Publicado: (2011)

Methylene blue unresponsive methemoglobinemia
por: Patnaik, Sibabratta, et al.
Publicado: (2014)

Methylene blue unresponsive methemoglobinemia
por: Mirakbari, Seyed Mostafa
Publicado: (2014)

Russo's Methylene Blue Reaction
por: Rankin, T. Thomson
Publicado: (1912)

Methylene Blue in the Treatment of Cholera
por: Bryan, John
Publicado: (1952)

Methylene blue in covid-19
por: Scigliano, Giulio, et al.
Publicado: (2021)

COVID-19 and Methylene Blue
por: Wiwanitkit, Viroj
Publicado: (2021)

Methylene Blue in the Treatment of Cancer
por: Slack, Henry R.
Publicado: (1907)

Methylene Blue in Pulmonary Tuberculosis
Publicado: (1901)

Methylene Blue in Refractory Shock
por: Chalise, Som N, et al.
Publicado: (2022)

Selenoprotein P Regulates Synaptic Zinc and Reduces Tau Phosphorylation
por: Kiyohara, Arlene C. P., et al.
Publicado: (2021)

Methylene blue: Subduing the post COVID-19 blues!
por: Magoon, Rohan, et al.
Publicado: (2021)

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
por: Timm, Thomas, et al.
Publicado: (2008)

Ecofriendly and low-cost bio adsorbent for efficient removal of methylene blue from aqueous solution
por: Radoor, Sabarish, et al.
Publicado: (2022)

THE SELECTIVE BACTERICIDAL ACTION OF METHYLENE-BLUE
por: Churchman, John W.
Publicado: (1913)

Methylene Blue in the Cure of Ulcerative Stomatitis
Publicado: (1909)

On the Use of Methylene Blue in Malarial Fevers
por: Marshall, D. G., et al.
Publicado: (1893)

METHYLENE BLUE IN REFRACTORY SEPTIC SHOCK
por: Eliliwi, Mouhanned, et al.
Publicado: (2020)

Bile salt induced solubilization of methylene blue: Study on methylene blue fluorescence properties and molecular mechanics calculation
por: Selvam, Susithra, et al.
Publicado: (2017)

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau
por: Hochgräfe, Katja, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_8gqtv74mtaor3f7mgs69ml7b8t