Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example, TP53, PIK3CA,...

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Detalles Bibliográficos
Autores principales: Smid, Marcel, Rodríguez-González, F. Germán, Sieuwerts, Anieta M., Salgado, Roberto, Prager-Van der Smissen, Wendy J. C., Vlugt-Daane, Michelle van der, van Galen, Anne, Nik-Zainal, Serena, Staaf, Johan, Brinkman, Arie B., van de Vijver, Marc J., Richardson, Andrea L., Fatima, Aquila, Berentsen, Kim, Butler, Adam, Martin, Sancha, Davies, Helen R., Debets, Reno, Gelder, Marion E. Meijer-Van, van Deurzen, Carolien H. M., MacGrogan, Gaëtan, Van den Eynden, Gert G. G. M., Purdie, Colin, Thompson, Alastair M., Caldas, Carlos, Span, Paul N., Simpson, Peter T., Lakhani, Sunil R., Van Laere, Steven, Desmedt, Christine, Ringnér, Markus, Tommasi, Stefania, Eyford, Jorunn, Broeks, Annegien, Vincent-Salomon, Anne, Futreal, P. Andrew, Knappskog, Stian, King, Tari, Thomas, Gilles, Viari, Alain, Langerød, Anita, Børresen-Dale, Anne-Lise, Birney, Ewan, Stunnenberg, Hendrik G., Stratton, Mike, Foekens, John A., Martens, John W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052682/
https://www.ncbi.nlm.nih.gov/pubmed/27666519
http://dx.doi.org/10.1038/ncomms12910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052682/
https://www.ncbi.nlm.nih.gov/pubmed/27666519
http://dx.doi.org/10.1038/ncomms12910

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