Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

Small-molecule fragments binding to biomacromolecules can be starting points for the development of drugs, but are often difficult to detect due to low affinities. Here we present a strategy that identifies protein-binding fragments through their potential to induce the target-guided formation of co...

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Detalles Bibliográficos
Autores principales: Becker, Daniel, Kaczmarska, Zuzanna, Arkona, Christoph, Schulz, Robert, Tauber, Carolin, Wolber, Gerhard, Hilgenfeld, Rolf, Coll, Miquel, Rademann, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052702/
https://www.ncbi.nlm.nih.gov/pubmed/27677239
http://dx.doi.org/10.1038/ncomms12761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052702/
https://www.ncbi.nlm.nih.gov/pubmed/27677239
http://dx.doi.org/10.1038/ncomms12761

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