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Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments
Small-molecule fragments binding to biomacromolecules can be starting points for the development of drugs, but are often difficult to detect due to low affinities. Here we present a strategy that identifies protein-binding fragments through their potential to induce the target-guided formation of co...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052702/ https://www.ncbi.nlm.nih.gov/pubmed/27677239 http://dx.doi.org/10.1038/ncomms12761 |