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Boolean regulatory network reconstruction using literature based knowledge with a genetic algorithm optimization method

BACKGROUND: Prior knowledge networks (PKNs) provide a framework for the development of computational biological models, including Boolean models of regulatory networks which are the focus of this work. PKNs are created by a painstaking process of literature curation, and generally describe all relev...

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Detalles Bibliográficos
Autores principales: Dorier, Julien, Crespo, Isaac, Niknejad, Anne, Liechti, Robin, Ebeling, Martin, Xenarios, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053080/
https://www.ncbi.nlm.nih.gov/pubmed/27716031
http://dx.doi.org/10.1186/s12859-016-1287-z