Comparative analysis of anti-polyglutamine Fab crystals grown on Earth and in microgravity

Huntington’s disease is one of nine neurodegenerative diseases caused by a polyglutamine (polyQ)-repeat expansion. An anti-polyQ antigen-binding fragment, MW1 Fab, was crystallized both on Earth and on the International Space Station, a microgravity environment where convection is limited. Once the...

Descripción completa

Detalles Bibliográficos
Autores principales: Owens, Gwen E., New, Danielle M., Olvera, Alejandra I., Manzella, Julia Ashlyn, Macon, Brittney L., Dunn, Joshua C., Cooper, David A., Rouleau, Robyn L., Connor, Daniel S., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2016
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053161/
https://www.ncbi.nlm.nih.gov/pubmed/27710941
http://dx.doi.org/10.1107/S2053230X16014011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053161/
https://www.ncbi.nlm.nih.gov/pubmed/27710941
http://dx.doi.org/10.1107/S2053230X16014011

Ejemplares similares