Cargando…

Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory

Recent evidence has placed the unfolded protein response (UPR) at the centre of pathological processes leading to neurodegenerative disease. The translational repression caused by UPR activation starves neurons of the essential proteins they need to function and survive. Restoration of protein synth...

Descripción completa

Detalles Bibliográficos
Autores principales: Halliday, Mark, Mallucci, Giovanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053297/
https://www.ncbi.nlm.nih.gov/pubmed/25556298
http://dx.doi.org/10.1111/nan.12211