Gadd45b deficiency promotes premature senescence and skin aging

The GADD45 family of proteins functions as stress sensors in response to various physiological and environmental stressors. Here we show that primary mouse embryo fibroblasts (MEFs) from Gadd45b null mice proliferate slowly, accumulate increased levels of DNA damage, and senesce prematurely. The imp...

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Detalles Bibliográficos
Autores principales: Magimaidas, Andrew, Madireddi, Priyanka, Maifrede, Silvia, Mukherjee, Kaushiki, Hoffman, Barbara, Liebermann, Dan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053623/
https://www.ncbi.nlm.nih.gov/pubmed/27105496
http://dx.doi.org/10.18632/oncotarget.8854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053623/
https://www.ncbi.nlm.nih.gov/pubmed/27105496
http://dx.doi.org/10.18632/oncotarget.8854

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