Loss of PIG3 increases HIF-1α level by promoting protein synthesis via mTOR pathway in renal cell carcinoma cells

PIG3 is a target of the tumor suppressor p53 and is thought to be involved in p53-mediated cell apoptosis. Although PIG3 is similar to oxidoreductases involved in generating ROS, whether PIG3 would regulate HIF-1α was never characterized directly. Here we demonstrated that knockdown of PIG3 by trans...

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Detalles Bibliográficos
Autores principales: Chen, Guang, Xu, Jin-Ye, Chen, Jie, Zhang, Jian-Xin, Zhou, Jun, Liang, Yong, Ding, Xiao-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053640/
https://www.ncbi.nlm.nih.gov/pubmed/27029070
http://dx.doi.org/10.18632/oncotarget.8401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053640/
https://www.ncbi.nlm.nih.gov/pubmed/27029070
http://dx.doi.org/10.18632/oncotarget.8401

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