Period2 downregulation inhibits glioma cell apoptosis by activating the MDM2-TP53 pathway

The Period2 (Per2) gene is an essential component of the mammalian circadian clock and is strongly linked to glioma occurrence and its response to radiotherapy. Here, we examined the role of Per2 in the response to X-ray-induced DNA damage in U343 glioma cells and in a mouse cancer model. Following...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhanfeng, Niu, Chengquan, Wang, Hechun, Xia, Jun, Wang, Lijian, Zhang, Dede, Ma, Wenbin, Liu, Lei, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053655/
https://www.ncbi.nlm.nih.gov/pubmed/27036047
http://dx.doi.org/10.18632/oncotarget.8439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053655/
https://www.ncbi.nlm.nih.gov/pubmed/27036047
http://dx.doi.org/10.18632/oncotarget.8439

Ejemplares similares