Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: identification of functional disparities between azacytidine and decitabine

Polypharmacology (the ability of a drug to affect more than one molecular target) is considered a basic property of many therapeutic small molecules. Herein, we used a chemical genomics approach to systematically analyze polypharmacology by integrating several analytical tools, including the LINCS (...

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Detalles Bibliográficos
Autores principales: Hsieh, Yao-Yu, Huang, Tsui-Chin, Lo, Hsiang-Ling, Jhan, Jyun-Yan, Chen, Shui-Tein, Yang, Pei-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053656/
https://www.ncbi.nlm.nih.gov/pubmed/27036028
http://dx.doi.org/10.18632/oncotarget.8455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053656/
https://www.ncbi.nlm.nih.gov/pubmed/27036028
http://dx.doi.org/10.18632/oncotarget.8455

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