CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway

The mammalian target of rapamycin (mTOR) is a potentially important therapeutic target in a broad range of cancer types. mTOR inhibitors such as rapamycin and its analogs (rapalogs) have been proven effective as anticancer agents in non-small cell lung cancer (NSCLC), whereas they strongly enhance p...

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Detalles Bibliográficos
Autores principales: Wen, Qiuyuan, Wang, Weiyuan, Luo, Jiadi, Chu, Shuzhou, Chen, Lingjiao, Xu, Lina, Zang, Hongjing, Alnemah, Mohannad Ma, Ma, Jian, Fan, Songqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053688/
https://www.ncbi.nlm.nih.gov/pubmed/27050281
http://dx.doi.org/10.18632/oncotarget.8497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053688/
https://www.ncbi.nlm.nih.gov/pubmed/27050281
http://dx.doi.org/10.18632/oncotarget.8497

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