Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells

The aberrant energy homeostasis that characterized by high rate of energy production (glycolysis) and energy consumption (mRNA translation) is associated with the development of cancer. As mammalian target of rapamycin (mTOR) is a critical regulator of aberrant energy homeostasis, it is an attractiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Chao, Yang, Lei, Geng, Ya-di, An, Fa-liang, Xia, Yuan-zheng, Guo, Chao, Luo, Jian-guang, Zhang, Lu-yong, Guo, Qing-long, Kong, Ling-yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053690/
https://www.ncbi.nlm.nih.gov/pubmed/27056897
http://dx.doi.org/10.18632/oncotarget.8538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053690/
https://www.ncbi.nlm.nih.gov/pubmed/27056897
http://dx.doi.org/10.18632/oncotarget.8538

Ejemplares similares