High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition

The anti-apoptotic protein B cell lymphoma/leukaemia 2 (BCL-2) is highly expressed in neuroblastoma and plays an important role in oncogenesis. In this study, the selective BCL-2 inhibitor ABT199 was tested in a panel of neuroblastoma cell lines with diverse expression levels of BCL-2 and other BCL-...

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Detalles Bibliográficos
Autores principales: Bate-Eya, Laurel T., den Hartog, Ilona J.M., van der Ploeg, Ida, Schild, Linda, Koster, Jan, Santo, Evan E., Westerhout, Ellen M., Versteeg, Rogier, Caron, Huib N., Molenaar, Jan J., Dolman, M. Emmy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053701/
https://www.ncbi.nlm.nih.gov/pubmed/27056887
http://dx.doi.org/10.18632/oncotarget.8547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053701/
https://www.ncbi.nlm.nih.gov/pubmed/27056887
http://dx.doi.org/10.18632/oncotarget.8547

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