mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency

Tuberous sclerosis complex (TSC), caused by loss-of-function mutations in the TSC1 or TSC2 gene, is characterized by benign tumor formation in multiple organs. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) is the primary alteration underlying TSC tumors. By analyzing Tsc2-null...

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Detalles Bibliográficos
Autores principales: Li, Hongwu, Jin, Fuquan, Jiang, Keguo, Ji, Shuang, Wang, Li, Ni, Zhaofei, Chen, Xianguo, Hu, Zhongdong, Zhang, Hongbing, Liu, Yehai, Qin, Yide, Zha, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053737/
https://www.ncbi.nlm.nih.gov/pubmed/27078846
http://dx.doi.org/10.18632/oncotarget.8633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053737/
https://www.ncbi.nlm.nih.gov/pubmed/27078846
http://dx.doi.org/10.18632/oncotarget.8633

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