Cargando…

A reciprocal regulatory circuit between CD44 and FGFR2 via c-myc controls gastric cancer cell growth

Despite their suggested importance, the mechanistic roles of FGFR2 and gastric cancer stem cell (GCSC) marker CD44 remain unclear. We investigated cross talk between CD44 and FGFR2. FGFR2 and CD44 positively regulate each other's expression. While FGFR2 suppresses c-Myc transcription, CD44 acti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jihyun, Kim, Sun Young, Kim, Ha-Jung, Kim, Kyoung-Mee, Choi, Eun Young, Kang, Myung-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053754/ https://www.ncbi.nlm.nih.gov/pubmed/27107424 http://dx.doi.org/10.18632/oncotarget.8764

Ejemplares similares

Acquired resistance to LY2874455 in FGFR2-amplified gastric cancer through an emergence of novel FGFR2-ACSL5 fusion
por: Kim, Sun Young, et al.
Publicado: (2017)

Peritoneal Seeding Is More Common in Gastric Cancer Patients with FGFR2 Amplification or High Tumor Mutation Burden
por: Kim, Hyunjin, et al.
Publicado: (2022)

Reciprocal regulatory circuits coordinating EMT plasticity
por: Diepenbruck, Maren, et al.
Publicado: (2017)

Prognostic implications of FGFR1 and MYC status in esophageal squamous cell carcinoma
por: Kwon, Dohee, et al.
Publicado: (2016)

Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer
por: Yang, Ying, et al.
Publicado: (2019)

Incidence of FGFR2 Amplification and FGFR2 Fusion in Patients with Metastatic Cancer Using Clinical Sequencing
por: Hyung, Sujin, et al.
Publicado: (2022)

BGJ398, A Pan-FGFR Inhibitor, Overcomes Paclitaxel Resistance in Urothelial Carcinoma with FGFR1 Overexpression
por: Kim, Se Hyun, et al.
Publicado: (2018)

Expression of Leucine-rich Repeat-containing G-protein Coupled Receptor 5 and CD44: Potential Implications for Gastric Cancer Stem Cell Marker
por: Choi, Yoon Jin, et al.
Publicado: (2016)

CD44 Variant 9 Serves as a Poor Prognostic Marker in Early Gastric Cancer, But Not in Advanced Gastric Cancer
por: Go, Se-Il, et al.
Publicado: (2016)

The prognostic effects of tumor infiltrating regulatory T cells and myeloid derived suppressor cells assessed by multicolor flow cytometry in gastric cancer patients
por: Choi, Han Sol, et al.
Publicado: (2016)

Sense–antisense miRNA pairs constitute an elaborate reciprocal regulatory circuit
por: Song, Yulong, et al.
Publicado: (2020)

Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response
por: Cho, Junhun, et al.
Publicado: (2016)

Detection of Epstein-Barr Virus by PCR and Expression of LMP1, p53, CD44 in Gastric Cancer
por: Lee, Myung Ah, et al.
Publicado: (2004)

Pathological and Prognostic Impacts of FGFR2 Overexpression in Gastric Cancer: A Meta-Analysis
por: Kim, Hyeong Su, et al.
Publicado: (2019)

Foretinib Inhibits Cancer Stemness and Gastric Cancer Cell Proliferation by Decreasing CD44 and c-MET Signaling
por: Sohn, Sung-Hwa, et al.
Publicado: (2020)

Detection of Malignant Cells in Pleural Fluid or Ascites by CD44v8-10/CD44v10 competitive RT-PCR
por: Ahn, Myung-Ju, et al.
Publicado: (2001)

Expression of CD274 mRNA Measured by qRT-PCR Correlates With PD-L1 Immunohistochemistry in Gastric and Urothelial Carcinoma
por: Kang, So Young, et al.
Publicado: (2022)

Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL
por: Piya, Sujan, et al.
Publicado: (2022)

CD44 Disruption Attenuates Murine Hepatic Ischemia/Reperfusion Injury
por: Kim, Min Sung, et al.
Publicado: (2011)

Nomogram Incorporating CD44v6 and Clinicopathological Factors to Predict Lymph Node Metastasis for Early Gastric Cancer
por: Eom, Bang Wool, et al.
Publicado: (2016)

Clinical relevance of TRKA expression on neuroblastoma: comparison with N-MYC amplification and CD44 expression.
por: Combaret, V., et al.
Publicado: (1997)

Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases
por: Park, Eun Su, et al.
Publicado: (2012)

CD44v8-10 as a potential theranostic biomarker for targeting disseminated cancer cells in advanced gastric cancer
por: Choi, Eun-Seok, et al.
Publicado: (2017)

Convergence Circuit Mapping: Genetic Approaches From Structure to Function
por: Yook, Jang Soo, et al.
Publicado: (2021)

Exuberant squamous metaplasia of the gastric mucosa in a patient with gastric adenocarcinoma
por: Ahn, Sangjeong, et al.
Publicado: (2015)

A NANOG‐pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamics
por: Kale, Hanuman T, et al.
Publicado: (2022)

Bacillus Calmette-Guérin Suppresses Asthmatic Responses via CD4(+)CD25(+) Regulatory T Cells and Dendritic Cells
por: Kim, Young-Joon, et al.
Publicado: (2014)

Immunohistochemical analysis of CD44s and CD44v6 in endometriosis and adenomyosis : comparison with normal, hyperplastic, and malignant endometrium.
por: Lin, Z., et al.
Publicado: (2001)

CD44 is involved in liver regeneration through enhanced uptake of extracellular cystine
por: Kim, Hyun Young, et al.
Publicado: (2022)

Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer
por: Elakad, Omar, et al.
Publicado: (2022)

In vivo monitoring of CD44(+) cancer stem-like cells by γ-irradiation in breast cancer
por: KIM, MI HYUN, et al.
Publicado: (2016)

Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
por: Wilson, Emily S., et al.
Publicado: (2021)

Downregulation of CD44 reduces doxorubicin resistance of CD44(+)CD24(−) breast cancer cells
por: Van Phuc, Pham, et al.
Publicado: (2011)

FGFR2 amplification is predictive of sensitivity to regorafenib in gastric and colorectal cancers in vitro
por: Cha, Yongjun, et al.
Publicado: (2018)

The First Case of B-lymphoblastic Leukemia Associated With t(7;8)(q34;p11.2) and FGFR1 Rearrangement
por: Cho, Ha-eun, et al.
Publicado: (2022)

The Role of CD44 in the Pathogenesis, Diagnosis, and Therapy of Gastric Cancer
por: Jang, Byung Ik, et al.
Publicado: (2011)

Alterations and Co-Occurrence of C-MYC, N-MYC, and L-MYC Expression are Related to Clinical Outcomes in Various Cancers
por: Lee, Moonjung, et al.
Publicado: (2023)

Prognostic significance of CD44s expression in resected non-small cell lung cancer
por: Ko, Yoon Ho, et al.
Publicado: (2011)

Responses to the Tepotinib in Gastric Cancers with MET Amplification or MET Exon 14 Skipping Mutations and High Expression of Both PD-L1 and CD44
por: Sohn, Sung-Hwa, et al.
Publicado: (2022)

Nutrition Intervention in a Gastric Cancer Patient With Gastrectomy for 12 Months: A Case Report
por: Youn, So Young, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7eb1uv8pud04q383u9gmj7fund