Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small cell lung cancer in preclinical models

Continuous de novo fatty acid synthesis is a common feature of cancer required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but traditionally intractable drug target. Here, we provide genetic a...

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Detalles Bibliográficos
Autores principales: Svensson, Robert U., Parker, Seth J., Eichner, Lillian J., Kolar, Matthew J., Wallace, Martina, Brun, Sonja N., Lombardo, Portia S., Van Nostrand, Jeanine L., Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F., Harwood, H. James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M., Shaw, Reuben J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053891/
https://www.ncbi.nlm.nih.gov/pubmed/27643638
http://dx.doi.org/10.1038/nm.4181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053891/
https://www.ncbi.nlm.nih.gov/pubmed/27643638
http://dx.doi.org/10.1038/nm.4181

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