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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small cell lung cancer in preclinical models
Continuous de novo fatty acid synthesis is a common feature of cancer required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but traditionally intractable drug target. Here, we provide genetic a...
Autores principales: | Svensson, Robert U., Parker, Seth J., Eichner, Lillian J., Kolar, Matthew J., Wallace, Martina, Brun, Sonja N., Lombardo, Portia S., Van Nostrand, Jeanine L., Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F., Harwood, H. James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M., Shaw, Reuben J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053891/ https://www.ncbi.nlm.nih.gov/pubmed/27643638 http://dx.doi.org/10.1038/nm.4181 |
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