Comparative Genomic Study Reveals a Transition from TA Richness in Invertebrates to GC Richness in Vertebrates at CpG Flanking Sites: An Indication for Context-Dependent Mutagenicity of Methylated CpG Sites

Vertebrate genomes are characterized with CpG deficiency, particularly for GC-poor regions. The GC content-related CpG deficiency is probably caused by context-dependent deamination of methylated CpG sites. This hypothesis was examined in this study by comparing nucleotide frequencies at CpG flankin...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Leung, Frederick C.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054122/
https://www.ncbi.nlm.nih.gov/pubmed/19329065
http://dx.doi.org/10.1016/S1672-0229(09)60002-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054122/
https://www.ncbi.nlm.nih.gov/pubmed/19329065
http://dx.doi.org/10.1016/S1672-0229(09)60002-4

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