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Comparative Genomic Study Reveals a Transition from TA Richness in Invertebrates to GC Richness in Vertebrates at CpG Flanking Sites: An Indication for Context-Dependent Mutagenicity of Methylated CpG Sites
Vertebrate genomes are characterized with CpG deficiency, particularly for GC-poor regions. The GC content-related CpG deficiency is probably caused by context-dependent deamination of methylated CpG sites. This hypothesis was examined in this study by comparing nucleotide frequencies at CpG flankin...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054122/ https://www.ncbi.nlm.nih.gov/pubmed/19329065 http://dx.doi.org/10.1016/S1672-0229(09)60002-4 |