Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin

eEF1A2 is one of the isoforms of the alpha subunit of the eukaryotic Elongation Factor 1. It is overexpressed in human tumors and is endowed with oncogenic properties, favoring tumor cell proliferation while inhibiting apoptosis. We demonstrate that plitidepsin, an antitumor agent of marine origin t...

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Detalles Bibliográficos
Autores principales: Losada, Alejandro, Muñoz-Alonso, María José, García, Carolina, Sánchez-Murcia, Pedro A., Martínez-Leal, Juan Fernando, Domínguez, Juan Manuel, Lillo, M. Pilar, Gago, Federico, Galmarini, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054363/
https://www.ncbi.nlm.nih.gov/pubmed/27713531
http://dx.doi.org/10.1038/srep35100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054363/
https://www.ncbi.nlm.nih.gov/pubmed/27713531
http://dx.doi.org/10.1038/srep35100

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