Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor α Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI

Outgrowth of metastases expressing ERα mutations Y537S and D538G is common after endocrine therapy for estrogen receptor α (ERα) positive breast cancer. The effect of replacing wild type ERα in breast cancer cells with these mutations was unclear. We used the CRISPR-Cas9 genome editing system and ho...

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Detalles Bibliográficos
Autores principales: Mao, Chengjian, Livezey, Mara, Kim, Ji Eun, Shapiro, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054422/
https://www.ncbi.nlm.nih.gov/pubmed/27713477
http://dx.doi.org/10.1038/srep34753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054422/
https://www.ncbi.nlm.nih.gov/pubmed/27713477
http://dx.doi.org/10.1038/srep34753

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