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Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor α Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI

Outgrowth of metastases expressing ERα mutations Y537S and D538G is common after endocrine therapy for estrogen receptor α (ERα) positive breast cancer. The effect of replacing wild type ERα in breast cancer cells with these mutations was unclear. We used the CRISPR-Cas9 genome editing system and ho...

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Detalles Bibliográficos
Autores principales:	Mao, Chengjian, Livezey, Mara, Kim, Ji Eun, Shapiro, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054422/ https://www.ncbi.nlm.nih.gov/pubmed/27713477 http://dx.doi.org/10.1038/srep34753

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