Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver

The aryl hydrocarbon receptor (Ahr) is a highly conserved nuclear receptor that plays an important role in the manifestation of toxicity induced by polycyclic aromatic hydrocarbons. As a xenobiotic sensor, Ahr is involved in chemical biotransformation through activation of drug metabolizing enzymes....

Descripción completa

Detalles Bibliográficos
Autores principales: Amenya, Hesbon Z., Tohyama, Chiharu, Ohsako, Seiichiroh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054525/
https://www.ncbi.nlm.nih.gov/pubmed/27713569
http://dx.doi.org/10.1038/srep34989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054525/
https://www.ncbi.nlm.nih.gov/pubmed/27713569
http://dx.doi.org/10.1038/srep34989

Ejemplares similares