Mechanism of high affinity inhibition of the human urate transporter URAT1

Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. We exploited affinity differences between the human and rat transporters to map inhibitor binding sites in URAT1. Human-rat transporter chimeras revealed that human URAT1 serine-...

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Detalles Bibliográficos
Autores principales: Tan, Philip K., Ostertag, Traci M., Miner, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054527/
https://www.ncbi.nlm.nih.gov/pubmed/27713539
http://dx.doi.org/10.1038/srep34995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054527/
https://www.ncbi.nlm.nih.gov/pubmed/27713539
http://dx.doi.org/10.1038/srep34995

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