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Structural insights into conformational stability of both wild-type and mutant EZH2 receptor

Polycomb group (PcG) proteins have been observed to maintain the pattern of histone by methylation of the histone tail responsible for the gene expression in various cellular processes, of which enhancer of zeste homolog 2 (EZH2) acts as tumor suppressor. Overexpression of EZH2 results in hyper acti...

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Detalles Bibliográficos
Autores principales: Aier, Imlimaong, Varadwaj, Pritish Kumar, Raj, Utkarsh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054529/
https://www.ncbi.nlm.nih.gov/pubmed/27713574
http://dx.doi.org/10.1038/srep34984