Cargando…

Structural insights into conformational stability of both wild-type and mutant EZH2 receptor

Polycomb group (PcG) proteins have been observed to maintain the pattern of histone by methylation of the histone tail responsible for the gene expression in various cellular processes, of which enhancer of zeste homolog 2 (EZH2) acts as tumor suppressor. Overexpression of EZH2 results in hyper acti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aier, Imlimaong, Varadwaj, Pritish Kumar, Raj, Utkarsh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054529/ https://www.ncbi.nlm.nih.gov/pubmed/27713574 http://dx.doi.org/10.1038/srep34984

Ejemplares similares

Identification of novel dysregulated key genes in Breast cancer through high throughput ChIP-Seq data analysis
por: Raj, Utkarsh, et al.
Publicado: (2017)

Author Correction: Identification of novel dysregulated key genes in Breast cancer through high throughput ChIP-Seq data analysis
por: Raj, Utkarsh, et al.
Publicado: (2020)

Understanding the Mechanism of Cell Death in Gemcitabine Resistant Pancreatic Ductal Adenocarcinoma: A Systems Biology Approach
por: Aier, Imlimaong, et al.
Publicado: (2019)

Unravelling the role of long non-coding RNA - LINC01087 in breast cancer
por: Tripathi, Rashmi, et al.
Publicado: (2019)

Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research
por: Sharma, Anju, et al.
Publicado: (2019)

An integrated epigenome and transcriptome analysis identifies PAX2 as a master regulator of drug resistance in high grade pancreatic ductal adenocarcinoma
por: Aier, Imlimaong, et al.
Publicado: (2019)

PGC1 alpha coactivates ERG fusion to drive antioxidant target genes under metabolic stress
por: Dhara, Aiindrila, et al.
Publicado: (2022)

Deciphering the Novel Target Genes Involved in the Epigenetics of Hepatocellular Carcinoma Using Graph Theory Approach
por: Roy, Nimisha, et al.
Publicado: (2019)

Effect of STAT3 inhibitor in chronic myeloid leukemia associated signaling pathway: a mathematical modeling, simulation and systems biology study
por: Kumar, Himansu, et al.
Publicado: (2016)

Transcriptomic Analysis of Soil Grown T. aestivum cv. Root to Reveal the Changes in Expression of Genes in Response to Multiple Nutrients Deficiency
por: Gupta, Saurabh, et al.
Publicado: (2017)

Prediction of suitable T and B cell epitopes for eliciting immunogenic response against SARS-CoV-2 and its mutant
por: Agarwal, Vidhu, et al.
Publicado: (2021)

OlfactionBase: a repository to explore odors, odorants, olfactory receptors and odorant–receptor interactions
por: Sharma, Anju, et al.
Publicado: (2021)

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors
por: Gibaja, V, et al.
Publicado: (2016)

FGO: A novel ontology for identification of ligand functional group
por: Varadwaj, Pritish Kumar, et al.
Publicado: (2007)

Functional group based Ligand binding affinity scoring function at atomic environmental level
por: Varadwaj, Pritish Kumar, et al.
Publicado: (2009)

HumDLoc: Human Protein Subcellular Localization Prediction Using Deep Neural Network
por: Semwal, Rahul, et al.
Publicado: (2020)

Insight into the structural stability of wild-type and histidine mutants in Pin1 by experimental and computational methods
por: Wang, Wang, et al.
Publicado: (2019)

Smelling the Disease: Diagnostic Potential of Breath Analysis
por: Sharma, Anju, et al.
Publicado: (2023)

A prediction model for oral bioavailability of drugs using physicochemical properties by support vector machine
por: Kumar, Rajnish, et al.
Publicado: (2011)

Integrated analysis of dysregulated lncRNA expression in breast cancer cell identified by RNA-seq study
por: Tripathi, Rashmi, et al.
Publicado: (2016)

Unraveling long non-coding RNAs through analysis of high-throughput RNA-sequencing data
por: Tripathi, Rashmi, et al.
Publicado: (2017)

Mutations responsible for the carbapenemase activity of SME-1
por: Agarwal, Vidhu, et al.
Publicado: (2022)

Stem cells: An overview with respect to cardiovascular and renal disease
por: Kumar, Rajnish, et al.
Publicado: (2010)

Production of Cystatin C Wild Type and Stabilized Mutants
por: Pollak, Joanna, et al.
Publicado: (2010)

Fungome: Annotating proteins implicated in fungal pathogenesis
por: Gudimella, Ranganath, et al.
Publicado: (2010)

Will there be a third COVID-19 wave? A SVEIRD model-based study of India’s situation
por: Kannan, Dwarakesh, et al.
Publicado: (2021)

Extrapolation of Inter Domain Communications and Substrate Binding Cavity of Camel HSP70 1A: A Molecular Modeling and Dynamics Simulation Study
por: Gupta, Saurabh, et al.
Publicado: (2015)

Docking-based Screening of Ficus religiosa Phytochemicals as Inhibitors of Human Histamine H2 Receptor
por: Chaudhary, Amit, et al.
Publicado: (2017)

Conformational changes on ligand binding in wild-type and mutants from Spodoptera frugiperda midgut trehalase
por: Silva, Walciane, et al.
Publicado: (2015)

In Silico Study of a Small Bioactive Molecule Targeting Topoisomerase II and P53-MDM2 Complex in Triple-Negative Breast Cancer
por: Singh, Vishal, et al.
Publicado: (2023)

The ezh2(sa1199) mutant zebrafish display no distinct phenotype
por: San, Bilge, et al.
Publicado: (2019)

Structural insights into conformational stability and binding of thiazolo-[2,3-b] quinazolinone derivatives with EGFR-TKD and in-vitro study
por: Ahmad Mir, Showkat, et al.
Publicado: (2022)

Conformational and structural stability of n and 2-propylthiols: a revisit
por: Tripathi, Manish Kumar, et al.
Publicado: (2022)

Conformational stability and structural analysis of methanethiol clusters: a revisit
por: Tripathi, Manish Kumar, et al.
Publicado: (2021)

Varying the expression pattern of the strigolactone receptor gene DAD2 results in phenotypes distinct from both wild type and knockout mutants
por: Drummond, Revel S. M., et al.
Publicado: (2023)

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
por: Bosco, Daryl A., et al.
Publicado: (2010)

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations
por: Wu, Hong, et al.
Publicado: (2013)

EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion
por: Yang, Xiang-Ping, et al.
Publicado: (2015)

Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
por: Woll, Kellie A., et al.
Publicado: (2021)

Che-1/AATF: A Critical Cofactor for Both Wild-Type- and Mutant-p53 Proteins
por: Bruno, Tiziana, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5k9q5cie8eb2jurjnsj062gcka