Perip7lakin is a target for autoimmunity in asthma

The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients...

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Autores principales: Taillé, Camille, Grootenboer-Mignot, Sabine, Estellat, Candice, Roy, Carine, Ly Ka So, Sophie, Pretolani, Marina, Aubier, Michel, Crestani, Bruno, Chollet-Martin, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054582/
https://www.ncbi.nlm.nih.gov/pubmed/27717390
http://dx.doi.org/10.1186/s12931-016-0441-5
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author Taillé, Camille
Grootenboer-Mignot, Sabine
Estellat, Candice
Roy, Carine
Ly Ka So, Sophie
Pretolani, Marina
Aubier, Michel
Crestani, Bruno
Chollet-Martin, Sylvie
author_facet Taillé, Camille
Grootenboer-Mignot, Sabine
Estellat, Candice
Roy, Carine
Ly Ka So, Sophie
Pretolani, Marina
Aubier, Michel
Crestani, Bruno
Chollet-Martin, Sylvie
author_sort Taillé, Camille
collection PubMed
description The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with no association with severity or atopy. In addition, anti-periplakin IgE antibodies were detected in 12 of 138 tested patients (8.7 %) and were more frequently observed in patients with than without nasal polyposis. This study identifies a new autoimmune epithelial target in asthma. Whether periplakin autoimmunity (both IgG and IgE auto-antibodies) is involved in asthma pathogenesis remains to be studied during the disease course of these patients.
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spelling pubmed-50545822016-10-19 Perip7lakin is a target for autoimmunity in asthma Taillé, Camille Grootenboer-Mignot, Sabine Estellat, Candice Roy, Carine Ly Ka So, Sophie Pretolani, Marina Aubier, Michel Crestani, Bruno Chollet-Martin, Sylvie Respir Res Letter to the Editor The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with no association with severity or atopy. In addition, anti-periplakin IgE antibodies were detected in 12 of 138 tested patients (8.7 %) and were more frequently observed in patients with than without nasal polyposis. This study identifies a new autoimmune epithelial target in asthma. Whether periplakin autoimmunity (both IgG and IgE auto-antibodies) is involved in asthma pathogenesis remains to be studied during the disease course of these patients. BioMed Central 2016-10-07 2016 /pmc/articles/PMC5054582/ /pubmed/27717390 http://dx.doi.org/10.1186/s12931-016-0441-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Taillé, Camille
Grootenboer-Mignot, Sabine
Estellat, Candice
Roy, Carine
Ly Ka So, Sophie
Pretolani, Marina
Aubier, Michel
Crestani, Bruno
Chollet-Martin, Sylvie
Perip7lakin is a target for autoimmunity in asthma
title Perip7lakin is a target for autoimmunity in asthma
title_full Perip7lakin is a target for autoimmunity in asthma
title_fullStr Perip7lakin is a target for autoimmunity in asthma
title_full_unstemmed Perip7lakin is a target for autoimmunity in asthma
title_short Perip7lakin is a target for autoimmunity in asthma
title_sort perip7lakin is a target for autoimmunity in asthma
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054582/
https://www.ncbi.nlm.nih.gov/pubmed/27717390
http://dx.doi.org/10.1186/s12931-016-0441-5
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