Blockade of Interferon‐γ Normalizes Interferon‐Regulated Gene Expression and Serum CXCL10 Levels in Patients With Systemic Lupus Erythematosus

OBJECTIVE: To assess the safety and immunologic impact of inhibiting interferon‐γ (IFNγ) with AMG 811, a human IgG1 monoclonal antibody against IFNγ, in patients with systemic lupus erythematosus (SLE). METHODS: Twenty‐six patients with mild‐to‐moderate, stable SLE were administered placebo or a sin...

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Detalles Bibliográficos
Autores principales: Welcher, Andrew A., Boedigheimer, Michael, Kivitz, Alan J., Amoura, Zahir, Buyon, Jill, Rudinskaya, Alla, Latinis, Kevin, Chiu, Kit, Oliner, Kelly S., Damore, Michael A., Arnold, Gregory E., Sohn, Winnie, Chirmule, Narendra, Goyal, Lovely, Banfield, Christopher, Chung, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Systemic Lupus Erythematosus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054935/
https://www.ncbi.nlm.nih.gov/pubmed/26138472
http://dx.doi.org/10.1002/art.39248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054935/
https://www.ncbi.nlm.nih.gov/pubmed/26138472
http://dx.doi.org/10.1002/art.39248

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