Cargando…

Stabilization of tryptophan hydroxylase 2 by l‐phenylalanine‐induced dimerization

Tryptophan hydroxylase 2 (TPH2) catalyses the initial and rate‐limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression, obsessive compulsive disorder, and schizophrenia. Full‐length TPH2 is poorly characterized due to low purification quanti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tidemand, Kasper D., Christensen, Hans E. M., Hoeck, Niclas, Harris, Pernille, Boesen, Jane, Peters, Günther H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055035/ https://www.ncbi.nlm.nih.gov/pubmed/27761358 http://dx.doi.org/10.1002/2211-5463.12100

Ejemplares similares

Phenylalanine Binding Is Linked to Dimerization of the Regulatory Domain of Phenylalanine Hydroxylase
por: Zhang, Shengnan, et al.
Publicado: (2014)

The Amino Acid Specificity for Activation of Phenylalanine Hydroxylase Matches the Specificity for Stabilization of Regulatory Domain Dimers
por: Zhang, Shengnan, et al.
Publicado: (2015)

PKU mutation p.G46S prevents the stereospecific binding of l‐phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain
por: Leandro, João, et al.
Publicado: (2017)

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain
por: Patel, Dipali, et al.
Publicado: (2016)

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
por: Pataskar, Abhijeet, et al.
Publicado: (2022)

Molecular Dynamics Simulation of Tryptophan Hydroxylase-1: Binding Modes and Free Energy Analysis to Phenylalanine Derivative Inhibitors
por: Zhong, Hao, et al.
Publicado: (2013)

Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones
por: Underhaug, Jarl, et al.
Publicado: (2012)

Activation of Phenylalanine Hydroxylase by Phenylalanine Does Not Require Binding in the Active Site
por: Roberts, Kenneth M., et al.
Publicado: (2014)

Acetylation of Phenylalanine Hydroxylase and Tryptophan 2,3-Dioxygenase Alters Hepatic Aromatic Amino Acid Metabolism in Weaned Piglets
por: Huang, Lu, et al.
Publicado: (2020)

Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
por: Pataskar, Abhijeet, et al.
Publicado: (2022)

Recommendations for the nutrition management of phenylalanine hydroxylase deficiency
por: Singh, Rani H., et al.
Publicado: (2014)

Heat Capacities of l-Histidine, l-Phenylalanine, l-Proline, l-Tryptophan and l-Tyrosine
por: Pokorný, Václav, et al.
Publicado: (2021)

Structural Features of the Regulatory ACT Domain of Phenylalanine Hydroxylase
por: Carluccio, Carla, et al.
Publicado: (2013)

Mutations of the phenylalanine hydroxylase gene in Iranian patients with phenylketonuria
por: Biglari, Alireza, et al.
Publicado: (2015)

Dynamic Regulation of Phenylalanine Hydroxylase by Simulated Redox Manipulation
por: Fuchs, Julian E., et al.
Publicado: (2012)

Genotypes of patients with phenylalanine hydroxylase deficiency in the Wisconsin Amish
por: Schwoerer, Jessica Scott, et al.
Publicado: (2018)

Characterization of phenylalanine hydroxylase gene variants and analysis of genotype–phenotype correlation in patients with phenylalanine hydroxylase deficiency from Fujian Province, Southeastern China
por: Zhou, Jinfu, et al.
Publicado: (2022)

Mutations of the phenylalanine hydroxylase gene in patients with phenylketonuria in Shanxi, China
por: Zhou, Yong-An, et al.
Publicado: (2012)

Phenylalanine Hydroxylase Deficiency and Citrin Deficiency in a Chinese Infant
por: Ye, Jun, et al.
Publicado: (2015)

Mutation analysis of Phenylalanine hydroxylase gene in Iranian patients with Phenylketonuria
por: Rastegar Moghadam, Mahsa, et al.
Publicado: (2018)

Structural and Functional Impact of Seven Missense Variants of Phenylalanine Hydroxylase
por: Pecimonova, Martina, et al.
Publicado: (2019)

Optical Coherence Tomography to Assess Neurodegeneration in Phenylalanine Hydroxylase Deficiency
por: Lotz-Havla, Amelie S., et al.
Publicado: (2021)

Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase
por: Conde-Giménez, María, et al.
Publicado: (2022)

Phenylalanine hydroxylase mRNA rescues the phenylketonuria phenotype in mice
por: Cacicedo, Maximiliano L., et al.
Publicado: (2022)

E3 Ubiquitin Ligase APC/C(Cdh1) Regulation of Phenylalanine Hydroxylase Stability and Function
por: Tyagi, Apoorvi, et al.
Publicado: (2020)

Unravelling the Complex Denaturant and Thermal-Induced Unfolding Equilibria of Human Phenylalanine Hydroxylase
por: Conde-Giménez, María, et al.
Publicado: (2021)

Immunochemical characterization of brain and pineal tryptophan hydroxylase.
por: Chung, Y. I., et al.
Publicado: (2001)

Mutational and phenotypic spectrum of phenylalanine hydroxylase deficiency in Zhejiang Province, China
por: Chen, Ting, et al.
Publicado: (2018)

Asymmetric rotations and dimerization driven by normal to modulated phase transition in 4-biphenylcarboxy coupled l-phenylalaninate
por: Dey, Somnath, et al.
Publicado: (2023)

Engineered Escherichia coli platforms for tyrosine-derivative production from phenylalanine using phenylalanine hydroxylase and tetrahydrobiopterin-regeneration system
por: Satoh, Yasuharu, et al.
Publicado: (2023)

No Tryptophan, Tyrosine and Phenylalanine Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder
por: Bergwerff, Catharina Elisabeth, et al.
Publicado: (2016)

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation
por: Nowak, Elizabeth C., et al.
Publicado: (2012)

Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila()
por: Leiros, Hanna-Kirsti S., et al.
Publicado: (2013)

A Conserved Acidic Residue in Phenylalanine Hydroxylase Contributes to Cofactor Affinity and Catalysis
por: Ronau, Judith A., et al.
Publicado: (2014)

Phenylalanine 4-Hydroxylase Contributes to Endophytic Bacterium Pseudomonas fluorescens’ Melatonin Biosynthesis
por: Jiao, Jian, et al.
Publicado: (2021)

Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants
por: Sarodaya, Neha, et al.
Publicado: (2022)

Screening and mutation analysis of phenylalanine hydroxylase deficiency in newborns from Jiangxi province
por: Zeng, Baitao, et al.
Publicado: (2023)

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe(2+)-binding
por: Guo, Hou-Fu, et al.
Publicado: (2018)

Specificity of the Acute Tryptophan and Tyrosine Plus Phenylalanine Depletion and Loading Tests Part II: Normalisation of the Tryptophan and the Tyrosine Plus Phenylalanine to Competing Amino Acid Ratios in a New Control Formulation
por: Badawy, Abdulla A.-B., et al.
Publicado: (2010)

Lack of Tryptophan Hydroxylase-1 in Mice Results in Gait Abnormalities
por: Suidan, Georgette L., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_it04lf26rvrfr0fheetoshi36n