Paradoxical delay of senescence upon depletion of BRCA2 in telomerase‐deficient worms

BRCA2 is a multifunctional tumor suppressor involved in homologous recombination (HR), mitotic checkpoint regulation, and telomere homeostasis. Absence of Brca2 in mice results in progressive shortening of telomeres and senescence, yet cells are prone to neoplastic transformation with elongated telo...

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Detalles Bibliográficos
Autores principales: Kwon, Mi‐Sun, Min, Jaewon, Jeon, Hee‐Yeon, Hwang, Kwangwoo, Kim, Chuna, Lee, Junho, Joung, Je‐Gun, Park, Woong‐Yang, Lee, Hyunsook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055038/
https://www.ncbi.nlm.nih.gov/pubmed/27761361
http://dx.doi.org/10.1002/2211-5463.12109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055038/
https://www.ncbi.nlm.nih.gov/pubmed/27761361
http://dx.doi.org/10.1002/2211-5463.12109

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