The Mechanism of Proinflammatory HDL Generation in Sickle Cell Disease Is Linked to Cell-Free Hemoglobin via Haptoglobin

In sickle cell disease (SCD), the inflammatory properties of high-density lipoprotein (HDL) can be changed by cell-free hemoglobin (Hb), which is released into the blood during hemolysis. Hb in the plasma of SCD patients or mice can bind with HDL specifically inducing an inflammatory reaction. In ou...

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Detalles Bibliográficos
Autores principales: Ji, Xiang, Feng, Yimin, Tian, Hui, Meng, Wei, Wang, Weiling, Liu, Na, Zhang, Jun, Wang, Lingshu, Wang, Jian, Gao, Haiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055316/
https://www.ncbi.nlm.nih.gov/pubmed/27716784
http://dx.doi.org/10.1371/journal.pone.0164264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055316/
https://www.ncbi.nlm.nih.gov/pubmed/27716784
http://dx.doi.org/10.1371/journal.pone.0164264

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