Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing

Target-based screening is one of the major approaches in drug discovery. Besides the intended target, unexpected drug off-target interactions often occur, and many of them have not been recognized and characterized. The off-target interactions can be responsible for either therapeutic or side effect...

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Detalles Bibliográficos
Autores principales: Lim, Hansaim, Poleksic, Aleksandar, Yao, Yuan, Tong, Hanghang, He, Di, Zhuang, Luke, Meng, Patrick, Xie, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055357/
https://www.ncbi.nlm.nih.gov/pubmed/27716836
http://dx.doi.org/10.1371/journal.pcbi.1005135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055357/
https://www.ncbi.nlm.nih.gov/pubmed/27716836
http://dx.doi.org/10.1371/journal.pcbi.1005135

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