Prediction of drug interaction between oral adsorbent AST-120 and concomitant drugs based on the in vitro dissolution and in vivo absorption behavior of the drugs

PURPOSE: AST-120 is used to decrease the abundance of serum uremic toxins in treatment of chronic kidney disease; however, it could also adsorb concomitantly administered drugs. This study aimed to develop a prediction method for drug interaction between AST-120 and concomitantly administered drugs...

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Detalles Bibliográficos
Autores principales: Koya, Yohei, Uchida, Shinya, Machi, Yoshiki, Shobu, Yuko, Namiki, Noriyuki, Kotegawa, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055906/
https://www.ncbi.nlm.nih.gov/pubmed/27491774
http://dx.doi.org/10.1007/s00228-016-2102-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055906/
https://www.ncbi.nlm.nih.gov/pubmed/27491774
http://dx.doi.org/10.1007/s00228-016-2102-5

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