TNF-α Autocrine Feedback Loops in Human Monocytes: The Pro- and Anti-Inflammatory Roles of the TNF-α Receptors Support the Concept of Selective TNFR1 Blockade In Vivo

Selective TNFR1 blockade in inflammatory diseases is emerging as a clinical strategy. We studied the roles of the two TNF-α receptors, TNFR1 and TNFR2, in human monocytes, the principal producer of TNF-α and central to many TNF-α driven diseases. We hypothesised that TNF-α has pro- and anti-inflamma...

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Detalles Bibliográficos
Autores principales: Gane, Jennie M., Stockley, Robert A., Sapey, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055993/
https://www.ncbi.nlm.nih.gov/pubmed/27747245
http://dx.doi.org/10.1155/2016/1079851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055993/
https://www.ncbi.nlm.nih.gov/pubmed/27747245
http://dx.doi.org/10.1155/2016/1079851

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