Cargando…

TNF-α Autocrine Feedback Loops in Human Monocytes: The Pro- and Anti-Inflammatory Roles of the TNF-α Receptors Support the Concept of Selective TNFR1 Blockade In Vivo

Selective TNFR1 blockade in inflammatory diseases is emerging as a clinical strategy. We studied the roles of the two TNF-α receptors, TNFR1 and TNFR2, in human monocytes, the principal producer of TNF-α and central to many TNF-α driven diseases. We hypothesised that TNF-α has pro- and anti-inflamma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gane, Jennie M., Stockley, Robert A., Sapey, Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055993/ https://www.ncbi.nlm.nih.gov/pubmed/27747245 http://dx.doi.org/10.1155/2016/1079851

Ejemplares similares

Anti-TNF-α Drugs Differently Affect the TNFα-sTNFR System and Monocyte Subsets in Patients with Psoriasis
por: Gibellini, Lara, et al.
Publicado: (2016)

Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches
por: Saddala, Madhu Sudhana, et al.
Publicado: (2019)

YB-1 Interferes with TNFα–TNFR Binding and Modulates Progranulin-Mediated Inhibition of TNFα Signaling
por: Hessman, Christopher L., et al.
Publicado: (2020)

Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4(+)Foxp3(+) induced Treg cells in vitro and in vivo periphery in autoimmune diseases
por: Yang, Sujuan, et al.
Publicado: (2019)

Preclinical and clinical aspects of TNF-α and its receptors TNFR1 and TNFR2 in breast cancer
por: Martínez-Reza, Isela, et al.
Publicado: (2017)

Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion
por: Heaton, William L., et al.
Publicado: (2018)

Retinal degeneration in experimental coronavirus retinopathy (ECOR) is associated with increased TNF-α, soluble TNFR2 and altered TNF-α signaling
por: Hooper, Laura C., et al.
Publicado: (2005)

Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma
por: Tomolonis, Julie A, et al.
Publicado: (2023)

Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1
por: Cai, Xiaoli, et al.
Publicado: (2017)

Genetics in TNF-TNFR pathway: A complex network causing spondyloarthritis and conditioning response to anti-TNFα therapy
por: Aita, Ada, et al.
Publicado: (2018)

TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise
por: Townsend, Jeremy R., et al.
Publicado: (2015)

The effects of TNF‐α/TNFR2 in regulatory T cells on the microenvironment and progression of gastric cancer
por: Qu, Yang, et al.
Publicado: (2021)

The Changing Face of Spondyloarthropathies Under TNF α Blockade
por: Elkayam, Ori, et al.
Publicado: (2008)

Autocrine Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) α Differentially Modulate Cellular Sensitivity to TNF/LT-α Cytotoxicity in L929 Cells
por: Decoster, Els, et al.
Publicado: (1998)

TNFR/TNF-α signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis
por: Qian, Qing-Zeng, et al.
Publicado: (2017)

The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study
por: Gane, Jennie M., et al.
Publicado: (2015)

TNF-α promotes gallbladder cancer cell growth and invasion through autocrine mechanisms
por: ZHU, GUANGWEI, et al.
Publicado: (2014)

SMAC Mimetics Synergistically Cooperate with HDAC Inhibitors Enhancing TNF-α Autocrine Signaling
por: Shibuya, Yusuke, et al.
Publicado: (2023)

TNF-α-induced ICAM-1 expression and monocyte adhesion in human RPE cells is mediated in part through autocrine VEGF stimulation
por: Thichanpiang, Peeradech, et al.
Publicado: (2014)

Editorial: Targeting TNF/TNFR signaling pathways
por: Pan, Liqiang, et al.
Publicado: (2023)

Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections
por: Ruiz, Andy, et al.
Publicado: (2021)

TNF-α Affects Signature Cytokines of Th1 and Th17 T Cell Subsets through Differential Actions on TNFR1 and TNFR2
por: Pesce, Bárbara, et al.
Publicado: (2022)

TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α
por: Bruggeman, Leslie A., et al.
Publicado: (2011)

The TNF-α/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response
por: Moatti, Audrey, et al.
Publicado: (2021)

Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity
por: Barker, Katie H., et al.
Publicado: (2022)

The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
por: Khan, Abrar Ul Haq, et al.
Publicado: (2023)

An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro
por: Urbano, Paulo C. M., et al.
Publicado: (2018)

Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis
por: Pękalski, Jakub, et al.
Publicado: (2013)

TNFα increases tyrosine hydroxylase expression in human monocytes
por: Gopinath, Adithya, et al.
Publicado: (2021)

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis
por: Yu, Hanjie, et al.
Publicado: (2022)

Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures
por: Steelman, Andrew J, et al.
Publicado: (2011)

TNF-α enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways
por: Jiang, Yuxue, et al.
Publicado: (2019)

TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function
por: Beldi, Ghada, et al.
Publicado: (2020)

Role of TGF-β in Survival of Phagocytizing Microglia: Autocrine Suppression of TNF-α Production and Oxidative Stress
por: Ryu, Keun-Young, et al.
Publicado: (2012)

TNFα inhibitor C87 sensitizes EGFRvIII transfected glioblastoma cells to gefitinib by a concurrent blockade of TNFα signaling
por: Ma, Li, et al.
Publicado: (2019)

Behҫet’s Disease, and the Role of TNF-α and TNF-α Blockers
por: van der Houwen, Tim, et al.
Publicado: (2020)

TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes
por: Dai, Fang-fang, et al.
Publicado: (2022)

Polymorphic Variants of TNFR2 Gene in Schizophrenia and Its Interaction with -308G/A TNF-α Gene Polymorphism
por: Suchanek-Raif, Renata, et al.
Publicado: (2018)

TNFR1 and the TNFα axis as a targetable mediator of liver injury from stereotactic body radiation therapy
por: Cousins, Matthew M., et al.
Publicado: (2020)

A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity
por: Vargas, Juan Gamboa, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0a6svj7iorb9fokml4hgoqgdrn