Characterization of WY 14,643 and its Complex with Aldose Reductase

The peroxisome proliferator, WY 14,643 exhibits a pure non-competitive inhibition pattern in the aldehyde reduction and in alcohol oxidation activities of human Aldose reductase (hAR). Fluorescence emission measurements of the equilibrium dissociation constants, K(d), of oxidized (hAR•NADP(+)) and r...

Descripción completa

Detalles Bibliográficos
Autores principales: Sawaya, Michael R., Verma, Malkhey, Balendiran, Vaishnavi, Rath, Nigam P., Cascio, Duilio, Balendiran, Ganesaratnam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056380/
https://www.ncbi.nlm.nih.gov/pubmed/27721416
http://dx.doi.org/10.1038/srep34394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056380/
https://www.ncbi.nlm.nih.gov/pubmed/27721416
http://dx.doi.org/10.1038/srep34394

Ejemplares similares