CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge

The CD4 and the cryptic coreceptor binding sites of the HIV-1 envelope glycoprotein are key to viral attachment and entry. We developed new molecules comprising a CD4 mimetic peptide linked to anionic compounds (mCD4.1-HS(12) and mCD4.1-PS1), that block the CD4-gp120 interaction and simultaneously i...

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Detalles Bibliográficos
Autores principales: Ariën, Kevin K., Baleux, Françoise, Desjardins, Delphine, Porrot, Françoise, Coïc, Yves-Marie, Michiels, Johan, Bouchemal, Kawthar, Bonnaffé, David, Bruel, Timothée, Schwartz, Olivier, Le Grand, Roger, Vanham, Guido, Dereuddre-Bosquet, Nathalie, Lortat-Jacob, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056392/
https://www.ncbi.nlm.nih.gov/pubmed/27721488
http://dx.doi.org/10.1038/srep34829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056392/
https://www.ncbi.nlm.nih.gov/pubmed/27721488
http://dx.doi.org/10.1038/srep34829

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