Cargando…

CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge

The CD4 and the cryptic coreceptor binding sites of the HIV-1 envelope glycoprotein are key to viral attachment and entry. We developed new molecules comprising a CD4 mimetic peptide linked to anionic compounds (mCD4.1-HS(12) and mCD4.1-PS1), that block the CD4-gp120 interaction and simultaneously i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ariën, Kevin K., Baleux, Françoise, Desjardins, Delphine, Porrot, Françoise, Coïc, Yves-Marie, Michiels, Johan, Bouchemal, Kawthar, Bonnaffé, David, Bruel, Timothée, Schwartz, Olivier, Le Grand, Roger, Vanham, Guido, Dereuddre-Bosquet, Nathalie, Lortat-Jacob, Hugues
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056392/ https://www.ncbi.nlm.nih.gov/pubmed/27721488 http://dx.doi.org/10.1038/srep34829

Ejemplares similares

Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure
por: Suphaphiphat, Karunasinee, et al.
Publicado: (2023)

MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV(162P3) in Cynomolgus Macaques
por: Dereuddre-Bosquet, Nathalie, et al.
Publicado: (2012)

Broadly neutralizing antibodies potently inhibit cell-to-cell transmission of semen leukocyte-derived SHIV162P3
por: Suphaphiphat, Karunasinee, et al.
Publicado: (2020)

A recombinant measles virus vaccine strongly reduces SHIV viremia and virus reservoir establishment in macaques
por: Nzounza, Patrycja, et al.
Publicado: (2021)

The Key Role of Metal Adducts in the Differentiation of Phosphopeptide from Sulfopeptide Sequences by High-Resolution Mass Spectrometry
por: Piovesana, Susy, et al.
Publicado: (2022)

The Novel CXCL12γ Isoform Encodes an Unstructured Cationic Domain Which Regulates Bioactivity and Interaction with Both Glycosaminoglycans and CXCR4
por: Laguri, Cédric, et al.
Publicado: (2007)

Site-Selective Solid-Phase Synthesis of a CCR5 Sulfopeptide Library To Interrogate HIV Binding and Entry
por: Liu, Xuyu, et al.
Publicado: (2014)

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread
por: Compton, Alex A., et al.
Publicado: (2014)

Complement contributes to antibody-mediated protection against repeated SHIV challenge
por: Goldberg, Benjamin S., et al.
Publicado: (2023)

Plasmacytoid Dendritic Cell Dynamics Tune Interferon-Alfa Production in SIV-Infected Cynomolgus Macaques
por: Bruel, Timothée, et al.
Publicado: (2014)

Pharmacological Validation of Long-Term Treatment with Antiretroviral Drugs in a Model of SIV-Infected Non-Human Primates
por: Gelé, Thibaut, et al.
Publicado: (2022)

Inhibition of HIV Virus by Neutralizing Vhh Attached to Dual Functional Liposomes Encapsulating Dapivirine
por: Wang, Scarlet Xiaoyan, et al.
Publicado: (2016)

M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
por: Selhorst, Philippe, et al.
Publicado: (2013)

Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains
por: Monneau, Yoan R., et al.
Publicado: (2017)

P12-11. Resistance to the CD4 mimetic mini protein M48-U1 induces changes in a highly conserved region on the HIV-1 gp120 envelope protein
por: Grupping, K, et al.
Publicado: (2009)

A Temperature-Monitoring Vaginal Ring for Measuring Adherence
por: Boyd, Peter, et al.
Publicado: (2015)

Identification of CX3CR1(+) mononuclear phagocyte subsets involved in HIV-1 and SIV colorectal transmission
por: Cavarelli, Mariangela, et al.
Publicado: (2022)

Hijacking of the Pleiotropic Cytokine Interferon-γ by the Type III Secretion System of Yersinia pestis
por: Gendrin, Claire, et al.
Publicado: (2010)

MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency
por: Grupping, Katrijn, et al.
Publicado: (2012)

Is HIV-1 evolving to a less virulent form in humans?
por: Ariën, Kevin K., et al.
Publicado: (2007)

Syncytia formation by SARS‐CoV‐2‐infected cells
por: Buchrieser, Julian, et al.
Publicado: (2020)

Syncytia formation by SARS‐CoV‐2‐infected cells
por: Buchrieser, Julian, et al.
Publicado: (2021)

Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
por: Smith, Paul, et al.
Publicado: (2016)

Anticancer metallohelices: nanomolar potency and high selectivity
por: Kaner, Rebecca A., et al.
Publicado: (2016)

Towards a vaccine against AIDS
por: Vieillard, Vincent, et al.
Publicado: (2010)

Searching for Lower Female Genital Tract Soluble and Cellular Biomarkers: Defining Levels and Predictors in a Cohort of Healthy Caucasian Women
por: Kyongo, Jordan K., et al.
Publicado: (2012)

Shiv Nadar School students visit CERN
por: Poulaillon, Jimmy, et al.
Publicado: (2023)

Oral Vaccination Approaches for Anti-SHIV Immunity
por: Velarde de la Cruz, Erandi, et al.
Publicado: (2021)

Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae
por: Marlin, Romain, et al.
Publicado: (2019)

Correction: Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection
por: Echebli, Nadia, et al.
Publicado: (2018)

Signal Transduction by Cxc Chemokine Receptor 4: Stromal Cell–Derived Factor 1 Stimulates Prolonged Protein Kinase B and Extracellular Signal–Regulated Kinase 2 Activation in T Lymphocytes
por: Tilton, Bettina, et al.
Publicado: (2000)

Cynomolgus macaque IL37 polymorphism and control of SIV infection
por: Shiina, Takashi, et al.
Publicado: (2019)

Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4(+) T Cells
por: Obregon-Perko, Veronica, et al.
Publicado: (2020)

Activity of Xenoestrogens at Nanomolar Concentrations in the E-Screen Assay
por: Silva, Elisabete, et al.
Publicado: (2007)

Identification of Nanomolar Lectin Ligands by a Glycodendrimer Microarray
por: Laigre, Eugénie, et al.
Publicado: (2018)

Pulse dipolar EPR for determining nanomolar binding affinities
por: Ackermann, Katrin, et al.
Publicado: (2022)

Discovery of Nanomolar DCAF1 Small Molecule Ligands
por: Li, Alice Shi Ming, et al.
Publicado: (2023)

Pyrenebutyrate Pt(IV) Complexes with Nanomolar Anticancer Activity
por: Ahmedova, Anife, et al.
Publicado: (2023)

In memory of a Legend: Dr. Shiv Shankar Gupta
por: Chandra, Dinesh
Publicado: (2013)

SHIVs, monkeys, and anti-HIV-1 neutralizing antibodies
por: Martin, Malcolm A
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_q9isqubsr1ndfdvte8qcutnm9o