Hexokinase I N-terminal based peptide prevents the VDAC1-SOD1 G93A interaction and re-establishes ALS cell viability

Superoxide Dismutase 1 mutants associate with 20–25% of familial Amyotrophic Lateral Sclerosis (ALS) cases, producing toxic aggregates on mitochondria, notably in spinal cord. The Voltage Dependent Anion Channel isoform 1 (VDAC1) in the outer mitochondrial membrane is a docking site for SOD1 G93A mu...

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Detalles Bibliográficos
Autores principales: Magrì, Andrea, Belfiore, Ramona, Reina, Simona, Tomasello, Marianna Flora, Di Rosa, Maria Carmela, Guarino, Francesca, Leggio, Loredana, De Pinto, Vito, Messina, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056396/
https://www.ncbi.nlm.nih.gov/pubmed/27721436
http://dx.doi.org/10.1038/srep34802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056396/
https://www.ncbi.nlm.nih.gov/pubmed/27721436
http://dx.doi.org/10.1038/srep34802

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