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Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
Despite progress in drug development, a quantitative and physiological understanding of how small-molecule inhibitors act on cells is lacking. Here, we measure the signalling and proliferative response of individual primary T-lymphocytes to a combination of antigen, cytokine and drug. We uncover two...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056434/ https://www.ncbi.nlm.nih.gov/pubmed/27687249 http://dx.doi.org/10.1038/ncomms12428 |