Cargando…

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death

We have discovered that the accumulation of an anti-calcitonin receptor (anti-CTR) antibody conjugated to a fluorophore (mAb2C4:AF568) provides a robust signal for cells undergoing apoptotic programmed cell death (PCD). PCD is an absolute requirement for normal development of metazoan organisms. PCD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Furness, SGB, Hare, DL, Kourakis, A, Turnley, AM, Wookey, PJ
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056446/ https://www.ncbi.nlm.nih.gov/pubmed/27777788 http://dx.doi.org/10.1038/cddiscovery.2016.62

Ejemplares similares

Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma
por: Gupta, Pragya, et al.
Publicado: (2020)

Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy
por: Wookey, Peter, et al.
Publicado: (2021)

Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias
por: Andreassen, Kim Vietz, et al.
Publicado: (2014)

Strategic Development of an Immunotoxin for the Treatment of Glioblastoma and Other Tumours Expressing the Calcitonin Receptor
por: Gupta, Pragya, et al.
Publicado: (2021)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas
por: Ostrovskaya, Anna, et al.
Publicado: (2019)

Calcitonin receptor expression in medullary thyroid carcinoma
por: Cappagli, Virginia, et al.
Publicado: (2017)

Peripheral Calcitonin Gene-Related Peptide Receptor Activation and Mechanical Sensitization of the Joint in Rat Models of Osteoarthritis Pain
por: Bullock, Craig M, et al.
Publicado: (2014)

Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors
por: Deganutti, Giuseppe, et al.
Publicado: (2021)

Calcitonin/Amylin Receptors and Ramps
por: Sexton, Patrick M.
Publicado: (2001)

Inhibition of Programmed Death Receptor-1/Programmed Death Ligand-1 Interactions by Ginsenoside Metabolites
por: Yim, Nam-Hui, et al.
Publicado: (2020)

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy
por: Dal Maso, Emma, et al.
Publicado: (2018)

Identification of the calcitonin receptor in osteoarthritic chondrocytes
por: Segovia-Silvestre, Toni, et al.
Publicado: (2011)

Calcitonin Receptor-Zonula Occludens-1 Interaction Is Critical for Calcitonin-Stimulated Prostate Cancer Metastasis
por: Aljameeli, Ahmed, et al.
Publicado: (2016)

Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors
por: Lee, Sangmin
Publicado: (2021)

Dual action of the cannabinoid receptor 1 ligand arachidonyl-2′-chloroethylamide on calcitonin gene-related peptide release
por: Christiansen, Isabella Mai, et al.
Publicado: (2022)

Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals
por: Goda, Tadahiro, et al.
Publicado: (2018)

Programmed death ligand-1/programmed death-1 inhibition therapy and programmed death ligand-1 expression in urothelial bladder carcinoma
por: Yu, Wei-Bo, et al.
Publicado: (2019)

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology
por: Watkins, H A, et al.
Publicado: (2014)

The calcitonins : physiology and pharmacology /
por: Azria, M. (Moíse), 1936-
Publicado: (1989)

Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding
por: Banerjee, Sugato, et al.
Publicado: (2006)

Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological Actions
por: Fischer, J.A., et al.
Publicado: (2001)

Use of Programmed Death Receptor-1 and/or Programmed Death Ligand 1 Inhibitors for the Treatment of Brain Metastasis of Lung Cancer
por: Wang, Shiqiang, et al.
Publicado: (2020)

Oral calcitonin
por: Hamdy, Ronald C, et al.
Publicado: (2012)

Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23–60 of the calcitonin receptor-like receptor
por: Barwell, James, et al.
Publicado: (2010)

Incidence of Immune-Related Adverse Events with Program Death Receptor-1- and Program Death Receptor-1 Ligand-Directed Therapies in Genitourinary Cancers
por: Maughan, Benjamin L., et al.
Publicado: (2017)

Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis
por: Kauther, Max D, et al.
Publicado: (2011)

The Calcitonin/Calcitonin Gene-Related Peptide Family in Invertebrate Deuterostomes
por: Sekiguchi, Toshio
Publicado: (2018)

Expression of programmed death ligand 1 in drug-resistant osteosarcoma: An exploratory study()()
por: Skertich, Nicholas J., et al.
Publicado: (2021)

Overview of Calcitonin Gene-Related Peptide and Its Receptor
por: Aiyar, Nambi
Publicado: (2001)

Calcitonin receptor is required for T-antigen-induced prostate carcinogenesis
por: Kale, Ajay, et al.
Publicado: (2020)

Correction: Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding
por: Banerjee, Sugato, et al.
Publicado: (2006)

A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene‐related peptide and beyond
por: Garelja, Michael L., et al.
Publicado: (2022)

Modulation of Gut Microbiota: A Novel Paradigm of Enhancing the Efficacy of Programmed Death-1 and Programmed Death Ligand-1 Blockade Therapy
por: Wang, Yiming, et al.
Publicado: (2018)

Expression of the Calcitonin Receptor-like Receptor (CALCRL) in Normal and Neoplastic Tissues
por: Wende, Benjamin, et al.
Publicado: (2023)

Programmed death‐ligand 1 expression in swine chronic infections and enhancement of interleukin‐2 production via programmed death‐1/programmed death‐ligand 1 blockade
por: Ganbaatar, Otgontuya, et al.
Publicado: (2021)

Senescent cells re‐engineered to express soluble programmed death receptor‐1 for inhibiting programmed death receptor‐1/programmed death ligand‐1 as a vaccination approach against breast cancer
por: Chen, Zehong, et al.
Publicado: (2018)

Interactions between programmed death-1 and programmed death ligand-1 promote tolerance by blocking the T cell receptor-induced stop signal
por: Fife, Brian T., et al.
Publicado: (2009)

Programmed death ligand 1 gene silencing in murine glioma models reveals cell line-specific modulation of tumor growth in vivo
por: Blomberg, Evelina, et al.
Publicado: (2022)

Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors
por: Jiang, Jian, et al.
Publicado: (2022)

Correction: Calcitonin receptor is required for T-antigen-induced prostate carcinogenesis
por: Kale, Ajay, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_aa4ds1d1a9eghr37t2qaelmlgg