Polycomb enables primitive endoderm lineage priming in embryonic stem cells

Mouse embryonic stem cells (ESCs), like the blastocyst from which they are derived, contain precursors of the epiblast (Epi) and primitive endoderm (PrEn) lineages. While transient in vivo, these precursor populations readily interconvert in vitro. We show that altered transcription is the driver of...

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Detalles Bibliográficos
Autores principales: Illingworth, Robert S, Hölzenspies, Jurriaan J, Roske, Fabian V, Bickmore, Wendy A, Brickman, Joshua M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056788/
https://www.ncbi.nlm.nih.gov/pubmed/27723457
http://dx.doi.org/10.7554/eLife.14926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056788/
https://www.ncbi.nlm.nih.gov/pubmed/27723457
http://dx.doi.org/10.7554/eLife.14926

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